Upshot, n.
Etymology: [Up + shot, equivalent to scot share, reckoning. Cf. the phrase to cast up an account.]
Final issue; conclusion; the sum and substance; the end; the result; the consummation. I can not pursue with any safety this sport to the upshot. Shak. We account it frailty that threescore years and ten make the upshot of man's pleasurable existence. De Quincey.
Shades of meaning
Fernald has no entry of its own for upshot; he lists it under consequence.
Where he writes about it:
The event (L. e, out, and venio, come) is primarily exactly the same in meaning as outcome; but in use it is more nearly equivalent to upshot signifying the sum and substance of all effects, consequences, and results of a course of action. — from consequence
Antonyms
none given