Webster’s 1913 has no entry under this spelling.
Shades of meaning
Fernald has no entry of its own for in spite of; he lists it under notwithstanding.
Where he writes about it:
Notwithstanding simply states that circumstances shall not be or have not been allowed to withstand; despite and in spite of refer primarily to personal and perhaps spiteful opposition; as, he failed notwithstanding his good intentions; or, he persevered in spite of the most bitter hostility. — from notwithstanding
When despite and in spite of are applied to inanimate things, it is with something of personification; "in spite of the storm" is said as if the storm had a hostile purpose to oppose the undertaking. — from notwithstanding