Frustrate, v. t. [imp. & p. p. Frustrated; p. pr. & vb. n. Frustrating.]
1. To bring to nothing; to prevent from attaining a purpose; to disappoint; to defeat; to baffle; as, to frustrate a plan, design, or attempt; to frustrate the will or purpose. Shall the adversary thus obtain His end and frustrate thine Milton.
2. To make null; to nullifly; to render invalid or of no effect; as, to frustrate a conveyance or deed.
Syn. -- To balk; thwart; foil; baffle; defeat.
1 other Webster entry under this spelling
Frustrate, a.
Vain; ineffectual; useless; unprofitable; null; voil; nugatory; of no effect. "Our frustrate search." Shak.
Shades of meaning
Fernald has no entry of its own for frustrate; he lists it under hinder.
He lists it without comment; the entries above explain its neighbors.