Fatigue, v. t. [imp. & p. p. Fatigued; p. pr. & vb. n. Fatiguing, n.]
Etymology: [Cf. F. fatiguer. See Fatigue, n.]
To weary with labor or any bodily or mental exertion; to harass with toil; to exhaust the strength or endurance of; to tire.
Syn. -- To jade; tire; weary; bore. See Jade.
1 other Webster entry under this spelling
Fatigue, n.
1. Weariness from bodily labor or mental exertion; lassitude or exhaustion of strength.
2. The cause of weariness; labor; toil; as, the fatigues of war. Dryden.
3. The weakening of a metal when subjected to repeated vibrations or strains. Fatigue call (Mil.), a summons, by bugle or drum, to perform fatigue duties. -- Fatigue dress, the working dress of soldiers. -- Fatigue duty (Mil.), labor exacted from soldiers aside from the use of arms. Farrow. -- Fatigue party, a party of soldiers on fatigue duty.
Shades of meaning
Fernald has no entry of its own for fatigue; he lists it under tire.
He lists it without comment; the entries above explain its neighbors.